For the first time a model of the spread of HIV and other viruses in the body
Mar 26, 2019

For the first time a model of the spread of HIV and other viruses in the body

Mathematicians have created a model that describes the spatial spread of viruses in the body.

The development allows us to analyze the growth of the virus population in space and time and assess how their interaction with the immune system affects the course of the disease. The obtained results will be useful for the diagnosis and monitoring of HIV and herpes, myxovirus, measles and other viral infections. The article was published in the journal of Theoretical Biology.To fight HIV, a detailed presentation of the mechanism of infection in the body is necessary. Although many models have been developed that describe the interaction of HIV with the cell, some approximations are made in each of them that affect the full understanding of the development of infection. Mathematicians and physicians from RUDN have created a new model, which, unlike the previous ones, takes into account an important aspect of cell — virus interaction-spatial distribution. It extends previously obtained models and is a system of differential equations that describe the evolution of the viral population and immune cells in space and time. Moreover, the model is also applicable to the description of other viral diseases.When it enters the body of the carrier, the viral infection causes an immune response to destroy it. However, there are viruses that the security system cannot cope with. These include the human immunodeficiency virus (HIV). As a host cell, HIV chooses T lymphocytes, which in a healthy body can either destroy the infected cell, or activate other cells that can cope with it. HIV kills T-lymphocytes, and gradually their number decreases so that the human immune system can not cope with infectious agents. This leads to the last stage of HIV disease: acquired immune deficiency syndrome (AIDS).The researchers identified 3 possible outcomes of infection: curable, mild chronic or severe chronic. In the first case, it can be completely destroyed, in the second — stored in the body along with a chronic immune response. In the latter case, the immune system is depleted, which leads to a high viral load on the body. The authors conducted a detailed analysis of each result and found the relationship between the spread of viral infection and the interaction of the virus with the cell."From the point of view of mathematical modeling, the spread of infection in cell culture or tissue is described by solutions of the traveling wave type of reaction-diffusion equations. We investigated this issue taking into account the interaction of viral infection with immune cells. This kind of interaction occurs when viruses can infect immune response cells (lymphocytes) and multiply in them. The most famous example of such a virus is HIV. But this also applies to other viruses such as herpes, myxovirus, measles»,- commented on the results Vitaly Volpert, author, head of the laboratory of mathematical modeling in Biomedicine RUDN. This is reported by Rambler. Next: https://doctor.rambler.ru/pharma/41921600/?utm_content=rdoctor&utm_medium=read_more&utm_source=copylink

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